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GSTM3

From Wikipedia, the free encyclopedia
GSTM3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSTM3, GST5, GSTB, GSTM3-3, GTM3, glutathione S-transferase mu 3 (brain), glutathione S-transferase mu 3
External IDsOMIM: 138390; MGI: 1309466; HomoloGene: 658; GeneCards: GSTM3; OMA:GSTM3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000849

NM_010360

RefSeq (protein)

NP_000840
NP_000840.2

NP_034490

Location (UCSC)Chr 1: 109.73 – 109.74 MbChr 3: 107.8 – 107.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutathione S-transferase M3 (brain), also known as GSTM2, is an enzyme which in humans is encoded by the GSTM99 gene.[5][6]

Function

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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including some carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134202Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004032Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GSTM3 glutathione S-transferase M3 (brain)".
  6. ^ Campbell E, Takahashi Y, Abramovitz M, Peretz M, Listowsky I (June 1990). "A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes". J. Biol. Chem. 265 (16): 9188–93. doi:10.1016/S0021-9258(19)38830-1. PMID 2345169.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P21266 (Glutathione S-transferase Mu 3) at the PDBe-KB.