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Draft:Gimantan

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Gimantan
Clinical data
Other namesHemantane, Himantane, A-7.
Identifiers
PubChem CID
ChemSpider
Chemical and physical data
FormulaC16H27N
Molar mass233.399 g·mol−1
3D model (JSmol)
  • C1CCCN(CC1)C2C3CC4CC(C3)CC2C4

Gimantan (Hemantane) is a Russian monoamine oxidase inhibitor. It has an adamantane amine molecular structure and is similar to related agents such as amantadine and memantine.

It is patented for the treatment of pain and inflammation,[1] alcoholism:[2] Cerebral circulation:[3] and Parkinson’s disease.[4]

The dosage is standardized to 50mg Tablets:[5]

Synthesis

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Gimantan is synthesized, according to the Leuckart reaction, by heating adamantan-2-one and hexamethyleneimine in the presence of formic acid.[6][7][8]

References

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  1. ^ Елена Артуровна Вальдман, RU2559777C2 (2014).
  2. ^ RU2582966C2
  3. ^ RU2554502C2
  4. ^ RU2423981C2
  5. ^ Tsvetkova EA, Volkova MY, Stepanenko OB, Kislyak NA, Shcherbakova OV, Avdyunina NI, et al. (January 2002). "Gimantan Tablets: Analysis and Standardization". Pharmaceutical Chemistry Journal. 36 (1): 48–50. doi:10.1023/A:1015761110991.
  6. ^ Sergeeva MS, Grushevskaya LN, Pyatin BM, Avdyunina NI, Gaevaya LM, Klumova VS, et al. (November 2011). "Pharmaceutical analysis and standardization of gimantan parenteral dosage form". Pharmaceutical Chemistry Journal. 45 (8): 499–502. doi:10.1007/s11094-011-0664-1.
  7. ^ Seredenin SB, Voronina TA, Avdyunina NI, Pyatin BM, Morozov IS, Bykov NP, et al. (2010). "SU1825499 "N-(2-adamantyl)hexamethyleneimine hydrochloride with anticataleptic activity". Byull. Izobret. (in Russian). 4.
  8. ^ Tsvetkova EA, Volkova MY, Stepanenko OB, Avdyunina NI, Bol'shakova RF, Pyatin BM (November 2001). "Analysis and Standardization of the New Domestic Antiparkinsonian Drug Gimantan". Pharmaceutical Chemistry Journal. 35 (11): 635–638. doi:10.1023/A:1015158213734.


Category:Adamantanes Category:Amines Category:Antidementia agents Category:Antiparkinsonian agents