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Dan Barouch

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Dan Barouch
Born(1973-02-04)February 4, 1973[2]
Gottingen, Germany[3]
CitizenshipAmerican
EducationM.D. and Ph.D.
Alma materHarvard and Oxford
Spouse(s)Fina C. Barouch, M.D.
ChildrenSusanna and Natalie
Scientific career
FieldsVirology
InstitutionsBeth Israel Deaconess Medical Center Harvard Medical School, Ragon Institute MIT and Harvard[1]

Dan Hung Barouch is an American physician, immunologist, and virologist. He is known for his work on the pathogenesis and immunology of viral infections and the development of vaccine strategies for global infectious diseases. His research led to the development of vaccine candidates for HIV, Zika, influenza, tuberculosis, monkeypox, and COVID-19, including the Johnson & Johnson COVID-19 vaccine[4][5][6][7]. He was named the founding director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, and is a founding member and a steering committee member at the Ragon Institute[8].

Barouch is Director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center[9] and the William Bosworth Castle Professor of Medicine at Harvard Medical School[10]. He is also affiliated with the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery[11].

Barouch has authored over 400 original peer-reviewed research articles and 50 review articles on infectious diseases, viral pathogenesis, immune responses, and vaccine development[12][13][14]. He was elected to the National Academy of Medicine in 2020[15][16][17] and received the King Faisal Prize in Medicine in 2023 for his work[18].

Early Life and Education

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Barouch grew up in Potsdam, New York, in an academic family with his mother, a biochemist; his father, a professor of mathematics and computer science; and his sister, now a cardiologist[19].

He attended Harvard College at the age of 16. Barouch received his B.A. in biochemistry from Harvard University summa cum laude at the age of 20 in 1993. In 1995, at the age of 22, he received his Ph.D. in immunology from Oxford University as a Marshall Scholar[20].

A scholar and a violinist[21][22], Barouch's time at Oxford University under the mentorship of Sir Andrew McMichael shaped his interests in virology and immunology. Barouch returned to Boston in 1995 and attended Havard Medical School.

In 1999, he received his M.D. from Harvard Medical School with highest honors summa cum laude. He completed clinical residency training in internal medicine and fellowship training in infectious diseases at Massachusetts General Hospital and Brigham and Women's Hospital in Boston.[23]

In 2002, he established his independent research laboratory at age 29 at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston[24].

Personal Life

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Barouch is married to Fina C. Barouch, M.D., an ophthalmologist and vitreoretinal surgeon[25]. They have two daughters, Susanna and Natalie, and reside in Newton, Massachusetts.

Research and Career

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Barouch is a professor of medicine and professor of immunology at Harvard Medical School.[26] In 2012, he was named the founding director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center in Boston.[27][28] He is also a founding member and a steering committee member at the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University.[29][30] He was appointed the William Bosworth Castle Professor of Medicine at Harvard Medical School in 2020[31].


HIV research

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Barouch started to develop vaccine candidates against HIV and other infectious diseases while in graduate school and medical school. He launched his independent research laboratory at age 29. His early work involved the creation of vaccine platform technologies, including adjuvanted DNA vaccines and novel adenoviral vectors, including Ad26[32][33][34].

In 2000, while still in medical school, Barouch started researching the development of an HIV vaccine.[35] He reported that HIV vaccines reduced viral loads in preclinical studies but that viral escape from immune responses could undermine immune control[36]. In 2002, he published that a candidate HIV vaccine can suppress the virus in preclinical studies for a period of two years.[37] In 2006, he developed adenovirus vaccine vectors that evaded suppression by baseline vector immunity.[38][39] His research provided the scientific foundation for the Johnson & Johnson HIV vaccine candidate, including the creation of a set of "mosaic" proteins with Bette Korber, which improve immune responses against multiple strains of the virus.[29][40]

Barouch was promoted to Professor of Medicine at Harvard Medical School in 2010. Two years later, in 2012, he became the Founding Director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center[41].

From 2015 to 2018, Barouch co-led the HIV-V-0004 APPROACH study, testing the mosaic Ad26/Env vaccine in human subjects.[42] This vaccine was then advanced into clinical efficacy trials in Africa, North America, South America, and Europe with the National Institutes of Health, the Bill & Melinda Gates Foundation, Janssen, and others.[29][43]

Barouch has also worked on immunologic strategies to cure HIV infection.[44] In 2016 and 2018, he demonstrated the potential of combining therapeutic vaccines or broadly neutralizing antibodies with immune activators, also known as the "shock and kill" strategy.[45] Barouch has also discussed his research and has commented on the research of others in the media.[46]

Zika research

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In 2016, Barouch developed and tested the first Zika vaccines in preclinical studies.[47][48] These vaccines entered first-in-human trials later that year.[49]

COVID-19 research

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In February 2021, Barouch co-authored a paper on how a certain level of COVID-19 antibodies may provide lasting protection against the virus.[50][51]

Societies and awards

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In 2009, Barouch was elected to the American Society for Clinical Investigation.[52]

In 2013, he became a member of the Association of American Physicians.[23]

In 2016, Barouch was named honorary researcher at the centre de Recherche, Centre hospitalier de l'Université de Montréal[53] and was named a Bostonian of the Year by the Boston Globe Magazine.[47]

In 2017, Barouch was named the Investigator of the Year by the Massachusetts Society for Medical Research and received the Drexel Prize in Immunology from the Drexel University College of Medicine.[citation needed]

In 2019, Barouch received the Best Academic Research Team Vaccine Industry Excellence Award at the World Vaccine Congress.[23]

In 2020 he was elected to the National Academy of Medicine.

In 2021, he was awarded the George Ledlie Prize for his work towards the creation of the SARS-CoV-2 vaccine,[54] and was awarded the Bostonians of the Year Award by The Boston Globe.[55]

In 2023, he was jointly awarded the 2023 King Faisal Prize for Medicine with vaccinologist Sarah Gilbert.[56][57]

References

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  1. ^ "Dan H. Barouch, M.D., Ph.D." 2019-11-04. Retrieved 2024-10-28.
  2. ^ "Professor Dan Hung Barouch – King Faisal Prize". Retrieved 2024-11-14.
  3. ^ "Professor Dan Hung Barouch – King Faisal Prize". Retrieved 2024-11-14.
  4. ^ "Barouch Laboratory – Center for Virology and Vaccine Research (CVVR)". 4 November 2019.
  5. ^ "Dan Barouch receives Ledlie Prize for vaccine work". 6 August 2021.
  6. ^ "414 days at work, zero days off: Dan Barouch and the race to develop the Johnson & Johnson vaccine - the Boston Globe". The Boston Globe.
  7. ^ "Zika Vaccine Development Reveals Differences in Efficacy One Year on | Harvard Magazine". 13 December 2017.
  8. ^ https://ragoninstitute.org/
  9. ^ https://www.bidmc.org/about-bidmc/news/2020/10/barouch-named-to-nam
  10. ^ "Dan H. Barouch, M.D., Ph.D." 4 November 2019.
  11. ^ "Dan Barouch, MD, PhD | UCSF-Bay Area Center for AIDS Research (CFAR)".
  12. ^ https://pubmed.ncbi.nlm.nih.gov/?term=%28%28%28Barouch%2C+Dan%5BAuthor%5D%29+OR+%28Barouch%2C+Dan+H%5BAuthor%5D%29%29+OR+%28Barouch+DH%5BAuthor%5D%29%29+OR+%28Barouch%2C+Dh%5BAuthor%5D%29&sort=
  13. ^ "Dan Barouch | Harvard Catalyst Profiles | Harvard Catalyst".
  14. ^ "ORCID".
  15. ^ "National Academy of Medicine Elects New Members | Harvard Magazine". 22 October 2020.
  16. ^ "Dan Hung Barouch | Harvard Program in Virology".
  17. ^ https://nam.edu/national-academy-of-medicine-elects-100-new-members-2020/
  18. ^ "Professor Dan Hung Barouch – King Faisal Foundation".
  19. ^ "Jews in the News: Mark Bomback, Judy Blume and Dan Barouch | Tampa JCCS and Federation".
  20. ^ "Dan Barouch".
  21. ^ Quick, Jonathan D.; Fryer, Bronwyn (30 January 2018). The End of Epidemics: The Looming Threat to Humanity and How to Stop It. St. Martin's Publishing. ISBN 978-1-250-11778-6.
  22. ^ "Dan Barouch".
  23. ^ a b c "biography". Center for Virology and Vaccine Research. Archived from the original on 2019-10-03. Retrieved 2019-10-03.
  24. ^ https://www.bidmc.org/research/research-by-department/medicine/center-for-virology-and-vaccine-research/barouch-laboratory
  25. ^ "Fina Barouch, MD - Lahey Health".
  26. ^ Browning, Bil (July 12, 2019). "A new vaccine for HIV that would work worldwide is expanding human testing to America". www.lgbtqnation.com.
  27. ^ "Dr. Dan Barouch to lead Beth Israel Deaconess center for vaccine research - The Boston Globe". BostonGlobe.com.
  28. ^ "Novel HIV vaccine candidate is safe and induces immune response in healthy adults and monkeys". ScienceDaily.
  29. ^ a b c "HIV Vaccine Takes Big Step | Harvard Medical School". hms.harvard.edu. December 2017.
  30. ^ "Monoclonal antibodies show promise as effective HIV therapy". medicalxpress.com.
  31. ^ "Dan Hung Barouch | PhD Program in Immunology".
  32. ^ Quick, Jonathan D.; Fryer, Bronwyn (30 January 2018). The End of Epidemics: The Looming Threat to Humanity and How to Stop It. St. Martin's Publishing. ISBN 978-1-250-11778-6.
  33. ^ Abbink, P.; Lemckert, A. A.; Ewald, B. A.; Lynch, D. M.; Denholtz, M.; Smits, S.; Holterman, L.; Damen, I.; Vogels, R.; Thorner, A. R.; O'Brien, K. L.; Carville, A.; Mansfield, K. G.; Goudsmit, J.; Havenga, M. J.; Barouch, D. H. (2007). "Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D". Journal of Virology. 81 (9): 4654–4663. doi:10.1128/JVI.02696-06. PMC 1900173. PMID 17329340.
  34. ^ Quick, Dr Jonathan D.; Fryer, Bronwyn (January 30, 2018). The End of Epidemics: The Looming Threat to Humanity and How to Stop It. St. Martin's Publishing Group. ISBN 9781250117786 – via Google Books.
  35. ^ Singhal, Arvind; Rogers, Everett M.; Rogers, Dr Everett M. (October 3, 2003). Combating AIDS: Communication Strategies in Action. SAGE. ISBN 9780761997283 – via Google Books.
  36. ^ Barouch, D. H.; Kunstman, J.; Kuroda, M. J.; Schmitz, J. E.; Santra, S.; Peyerl, F. W.; Krivulka, G. R.; Beaudry, K.; Lifton, M. A.; Gorgone, D. A.; Montefiori, D. C.; Lewis, M. G.; Wolinsky, S. M.; Letvin, N. L. (2002). "Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes". Nature. 415 (6869): 335–339. doi:10.1038/415335a. PMID 11797012.
  37. ^ "HIV Plus". Plus. Here Publishing: 11. ISSN 1522-3086. Retrieved 2019-10-03.
  38. ^ "The Finding". The Scientist. 2008. p. 63.
  39. ^ Roberts, Diane M.; Nanda, Anjali; Havenga, Menzo J. E.; Abbink, Peter; Lynch, Diana M.; Ewald, Bonnie A.; Liu, Jinyan; Thorner, Anna R.; Swanson, Patricia E.; Gorgone, Darci A.; Lifton, Michelle A.; Lemckert, Angelique A. C.; Holterman, Lennart; Chen, Bing; Dilraj, Athmanundh; Carville, Angela; Mansfield, Keith G.; Goudsmit, Jaap; Barouch, Dan H. (2006). "Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity". Nature. 441 (7090): 239–243. Bibcode:2006Natur.441..239R. doi:10.1038/nature04721. PMID 16625206.
  40. ^ Assunção, Muri (13 July 2019). "Johnson & Johnson to start testing on new type of HIV vaccine in U.S. and Europe". nydailynews.com.
  41. ^ "Dr. Dan Barouch to lead Beth Israel Deaconess center for vaccine research - the Boston Globe". The Boston Globe.
  42. ^ Karim, Quarraisha Abdool; Karim, Salim S. Abdool; Baxter, Cheryl (January 20, 2017). The CAPRISA Clinical Trials: HIV Treatment and Prevention. Springer. ISBN 9783319475189 – via Google Books.
  43. ^ Mega, Emiliano Rodríguez (July 31, 2019). "'Mosaic' HIV vaccine to be tested in thousands of people across the world". Nature. 572 (7768): 165–166. Bibcode:2019Natur.572..165M. doi:10.1038/d41586-019-02319-8. PMID 31388154.
  44. ^ "World's second man cleared of AIDS virus invigorates quest for cure". Reuters. March 6, 2019 – via www.reuters.com.
  45. ^ "Monkeys reveal new clues toward elusive HIV vaccine and cure". Science | AAAS. March 9, 2018.
  46. ^ "Promising HIV vaccine to be tested with gay men and trans people". aidsmap. 22 July 2019. Retrieved 2019-10-03.
  47. ^ a b "Dan Barouch and Jim Collins: The researchers racing to stop Zika - The Boston Globe". BostonGlobe.com.
  48. ^ Mukherjee, Siddhartha (August 15, 2016). "The Race for a Zika Vaccine". The New Yorker – via www.newyorker.com.
  49. ^ Knapton, Sarah (August 4, 2016). "Zika vaccine gives complete protection and is ready for human trials, say scientists". The Telegraph – via www.telegraph.co.uk.
  50. ^ Krouse, Sarah (2021-02-21). "Elon Musk got 4,000 SpaceX workers to join a COVID-19 study. Here's what he learned". Wall Street Journal. Retrieved 2021-02-21 – via foxbusiness.com.
  51. ^ Bartsch, Yannic C.; Fischinger, Stephanie; Siddiqui, Sameed M.; Chen, Zhilin; Yu, Jingyou; Gebre, Makda; Atyeo, Caroline; Gorman, Matthew J.; Zhu, Alex Lee; Kang, Jaewon; Burke, John S.; Slein, Matthew; Gluck, Matthew J.; Beger, Samuel; Hu, Yiyuan; Rhee, Justin; Petersen, Eric; Mormann, Benjamin; de St Aubin, Michael; Hasdianda, Mohammad A.; Jambaulikar, Guruprasad; Boyer, Edward W.; Sabeti, Pardis C.; Barouch, Dan H.; Julg, Boris D.; Musk, Elon R.; Menon, Anil S.; Lauffenburger, Douglas A.; Nilles, Eric J.; Alter, Galit (2021-02-15). "Discrete SARS-CoV-2 antibody titers track with functional humoral stability". Nature Communications. 12 (1): 1018. Bibcode:2021NatCo..12.1018B. doi:10.1038/s41467-021-21336-8. PMC 7884400. PMID 33589636.
  52. ^ "The American Society for Clinical Investigation".
  53. ^ "Barouch, Dan H. | CHUM". www.chumontreal.qc.ca.
  54. ^ Parsons, Lian (2021-08-06). "Dan Barouch receives Ledlie Prize for vaccine work". Harvard Gazette. Retrieved 2024-10-28.
  55. ^ "2021 Bostonians of the Year". 2021-12-16. Retrieved 2024-10-28.
  56. ^ "Dan Barouch Awarded King Faisal Prize". Ragon Institute of Mass General, MIT, and Harvard. 6 January 2023. Retrieved 2024-11-14.
  57. ^ "Professor Dan Hung Barouch – King Faisal Prize". Retrieved 2024-11-14.
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