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DGCR5

From Wikipedia, the free encyclopedia
DGCR5
Identifiers
AliasesDGCR5, LINC00037, NCRNA00037, DiGeorge syndrome critical region gene 5 (non-protein coding), DiGeorge syndrome critical region gene 5
External IDsOMIM: 618040; GeneCards: DGCR5; OMA:DGCR5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)Chr 22: 18.97 – 19.03 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

In molecular biology, DiGeorge syndrome critical region gene 5 (non-protein coding), also known as DGCR5, is a long non-coding RNA. In humans, it is located on chromosome 22q11, at the ADU breakpoint associated with DiGeorge syndrome.[3] Its expression is regulated by the transcription factor REST (RE1-Silencing Transcription factor).[4]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000273032Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Sutherland HF, Wadey R, McKie JM, Taylor C, Atif U, Johnstone KA, Halford S, Kim UJ, Goodship J, Baldini A, Scambler PJ (Jul 1996). "Identification of a novel transcript disrupted by a balanced translocation associated with DiGeorge syndrome". American Journal of Human Genetics. 59 (1): 23–31. PMC 1915101. PMID 8659529.
  4. ^ Johnson R, Teh CH, Jia H, Vanisri RR, Pandey T, Lu ZH, Buckley NJ, Stanton LW, Lipovich L (Jan 2009). "Regulation of neural macroRNAs by the transcriptional repressor REST". RNA. 15 (1): 85–96. doi:10.1261/rna.1127009. PMC 2612765. PMID 19050060.

Further reading

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