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DDX19B

From Wikipedia, the free encyclopedia
DDX19B
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDDX19B, DBP5, DDX19, RNAh, DEAD-box helicase 19B
External IDsOMIM: 605812; MGI: 2148251; HomoloGene: 56032; GeneCards: DDX19B; OMA:DDX19B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001190786
NM_001190800
NM_172284

RefSeq (protein)

n/a

Location (UCSC)Chr 16: 70.29 – 70.34 MbChr 8: 111.73 – 111.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP-dependent RNA helicase DDX19B is an enzyme that in humans is encoded by the DDX19B gene.[5][6]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157349Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033658Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schmitt C, von Kobbe C, Bachi A, Pante N, Rodrigues JP, Boscheron C, Rigaut G, Wilm M, Seraphin B, Carmo-Fonseca M, Izaurralde E (Sep 1999). "Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p". EMBO J. 18 (15): 4332–47. doi:10.1093/emboj/18.15.4332. PMC 1171509. PMID 10428971.
  6. ^ a b "Entrez Gene: DDX19B DEAD (Asp-Glu-Ala-As) box polypeptide 19B".

Further reading

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