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Coenzyme F420-0:L-glutamate ligase

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Coenzyme F420-0:L-glutamate ligase
Identifiers
EC no.6.3.2.31
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Coenzyme F420-0:L-glutamate ligase (EC 6.3.2.31, CofE-AF, MJ0768, CofE) is an enzyme with systematic name L-glutamate:coenzyme F420-0 ligase (GDP-forming).[1][2] This enzyme catalyses the following chemical reaction

GTP + coenzyme F420-0 + L-glutamate GDP + phosphate + coenzyme F420-1

In some instances, this enzyme is fused with a coenzyme F420-1:gamma-L-glutamate ligase domain, so that the produced coenzyme F420-1 is quickly ligated to coenzyme F420-2.

References

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  1. ^ Li H, Graupner M, Xu H, White RH (August 2003). "CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii". Biochemistry. 42 (32): 9771–8. doi:10.1021/bi034779b. PMID 12911320.
  2. ^ Nocek B, Evdokimova E, Proudfoot M, Kudritska M, Grochowski LL, White RH, Savchenko A, Yakunin AF, Edwards A, Joachimiak A (September 2007). "Structure of an amide bond forming F(420):gamma-glutamyl ligase from Archaeoglobus fulgidus -- a member of a new family of non-ribosomal peptide synthases". Journal of Molecular Biology. 372 (2): 456–69. doi:10.1016/j.jmb.2007.06.063. PMC 2678844. PMID 17669425.
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