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Chaotropic activity

From Wikipedia, the free encyclopedia

Chaotropicity describes the entropic disordering of lipid bilayers and other biomacromolecules which is caused by substances dissolved in water. According to the original usage[1] and work carried out on cellular stress mechanisms and responses,[2][3][4] chaotropic substances do not necessarily disorder the structure of water.[5]

The chaotropic activities of solutes in the aqueous phase (e.g. ethanol, butanol, urea, MgCl2, and phenol) have been quantified using an agar-gelation assay.[6] Whereas chaotropicity was first applied to studies of ions,[1] it is equally applicable to alcohols, aromatics, ion mixtures, and other solutes.[2][3][7][8] Furthermore, hydrophobic substances known to stress cellular systems (including benzene and toluene) can chaotropically disorder macromolecules and induce a chaotrope-stress response in microbial cells, even though they partition into the hydrophobic domains of macromolecular systems.[4][9]

See also

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References

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  1. ^ a b Hamaguchi & Geiduschek (1962). "The Effect of Electrolytes on the Stability of the Deoxyribonucleate Helix". J. Am. Chem. Soc. 84 (8): 1329–1338. doi:10.1021/ja00867a001.
  2. ^ a b Hallsworth, J.E. (1998). "Ethanol-induced water stress in yeast". Journal of Fermentation and Bioengineering. 85 (2): 125–137. doi:10.1016/S0922-338X(97)86756-6.
  3. ^ a b Hallsworth, J.E., Heim, S. and Timmis, K. (2003). "Chaotropic solutes cause water stress in Pseudomonas putida". Environmental Microbiology. 5 (12): 1270–1280. doi:10.1111/j.1462-2920.2003.00478.x. PMID 14641573.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ a b Bhaganna, P.; et al. (2010). "Hydrophobic substances induce water stress in microbial cells". Microbial Biotechnology. 3 (6): 701–716. doi:10.1111/j.1751-7915.2010.00203.x. PMC 3815343. PMID 21255365.
  5. ^ Ball, P.; Hallsworth, J.E. (2015). "Water structure and chaotropicity: their uses, abuses and biological implications". Physical Chemistry Chemical Physics. 17 (13): 8297–8305. Bibcode:2015PCCP...17.8297B. doi:10.1039/C4CP04564E. PMID 25628033.
  6. ^ Cray, J.A.; et al. (2013). "A universal measure of chaotropicity and kosmotropicity". Environmental Microbiology. 15 (1): 287–296. doi:10.1111/1462-2920.12018. PMID 23145833.
  7. ^ Hallsworth, J.E.; et al. (2007). "Limits of life in MgCl2-containing environments: chaotropicity defines the window". Environmental Microbiology. 9 (3): 801–813. doi:10.1111/j.1462-2920.2006.01212.x. PMID 17298378.
  8. ^ Alves, F.L.; et al. (2015). "Concomitant osmotic and chaotropicity-induced stresses in Aspergillus wentii: compatible solutes determine the biotic window". Current Genetics. 61 (3): 457–477. doi:10.1007/s00294-015-0496-8. PMID 26055444. S2CID 14826577.
  9. ^ Cray, J.A.; et al. (2015). "Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms". Current Opinion in Biotechnology. 33: 228–259. doi:10.1016/j.copbio.2015.02.010. PMID 25841213.