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Calpain-9

From Wikipedia, the free encyclopedia
CAPN9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAPN9, GC36, nCL-4, calpain 9
External IDsOMIM: 606401; MGI: 1920897; HomoloGene: 38208; GeneCards: CAPN9; OMA:CAPN9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006615
NM_016452
NM_001319676

NM_023709

RefSeq (protein)

NP_001306605
NP_006606
NP_057536

NP_076198

Location (UCSC)Chr 1: 230.75 – 230.8 MbChr 8: 125.3 – 125.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.[5][6][7]

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135773Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031981Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K (May 1998). "Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract". Biol Chem. 379 (2): 175–184. doi:10.1515/bchm.1998.379.2.175. PMID 9524069. S2CID 37483841.
  6. ^ Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (Jul 2000). "Isolation of two novel genes, down-regulated in gastric cancer". Jpn J Cancer Res. 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMC 5926377. PMID 10835488.
  7. ^ a b "Entrez Gene: CAPN9 calpain 9".

Further reading

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