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CDP-diacylglycerol diphosphatase

From Wikipedia, the free encyclopedia
CDP-diacylglycerol diphosphatase
Identifiers
EC no.3.6.1.26
CAS no.62213-20-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a CDP-diacylglycerol diphosphatase (EC 3.6.1.26) is an enzyme that catalyzes the chemical reaction

CDP-diacylglycerol + H2O CMP + phosphatidate

Thus, the two substrates of this enzyme are CDP-diacylglycerol and H2O, whereas its two products are CMP and phosphatidate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is CDP-diacylglycerol phosphatidylhydrolase. Other names in common use include cytidine diphosphodiacylglycerol pyrophosphatase, and CDP diacylglycerol hydrolase. This enzyme participates in glycerophospholipid metabolism.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2POF.

References

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  • Raetz CR, Hirschberg CB, Dowhan W, Wickner WT, Kennedy EP (1972). "A membrane-bound pyrophosphatase in Escherichia coli catalyzing the hydrolysis of cytidine diphosphate-diglyceride". J. Biol. Chem. 247 (7): 2245–7. doi:10.1016/S0021-9258(19)45521-X. PMID 4335869.