The 2024–25 CAF Confederation Cup knockout stage will start on 2 April with the quarter-finals and end on 25 May 2025 with the second leg of the final to decide the champions of the 2024–25 CAF Confederation Cup. 8 teams will compete in the knockout stage.
Each tie in the knockout phase will be played over two legs, with each team playing one leg at home. The team scoring more goals on aggregate over the two legs will advance to the next round. If the aggregate score will be level, the away goals rule will be applied, i.e. the team that will score more goals away from home over the two legs will advance. If away goals will also be equal, then extra time will not be played and the winners will be decided by a penalty shoot-out (Regulations III. 26 & 27).
The mechanism of the draws for each round was as follows:
In the draw for the quarter-finals, the four group winners were seeded, and the four group runners-up were unseeded. The seeded teams were drawn against the unseeded teams, with the seeded teams hosting the second leg. Teams from the same group could not be drawn against each other, while teams from the same association could be drawn against each other.
In the draws for the semi-finals, there were no seedings, and teams from the same group or the same association could be drawn against each other. As the draws for the quarter-finals and semi-finals were held together before the quarter-finals were played, the identity of the quarter-final winners was not known at the time of the semi-final draw.
The bracket of the knockout stage was determined as follows:
Round
Matchups
Quarter-finals
(Group winners will host second leg, matchups decided by draw, teams from same group cannot play each other)
QF1
QF2
QF3
QF4
Semi-finals
(Matchups and order of legs decided by draw, between winners QF1, QF2, QF3, QF4)
SF1
SF2
Final
Winners SF1 and SF2 will face each other in two legs to decide the champions
The bracket was decided after the draw for the knockout stage, which was held on 20 February 2025, 17:00 AST (UTC+3) at the beIN Sports headquarters in Doha, Qatar.[2]
Simba
CS Constantine
RS Berkane
Stellenbosch
ASEC Mimosas
Zamalek
QF2 winner