2-haloacid dehalogenase (configuration-retaining)
| 2-haloacid dehalogenase (configuration-retaining) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.8.1.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2-haloacid dehalogenase (configuration-retaining) (EC 3.8.1.11, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-DEXr) is an enzyme with systematic name (S)-2-haloacid dehalogenase (configuration-retaining).[1][2] This enzyme catalyses the following chemical reaction
- (1) (S)-2-haloacid + H2O (S)-2-hydroxyacid + halide
- (2) (R)-2-haloacid + H2O (R)-2-hydroxyacid + halide
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids.
References
[edit]- ^ Weightman AJ, Weightman AL, Slater JH (August 1982). "Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms". Journal of General Microbiology. 128 (8): 1755–62. doi:10.1099/00221287-128-8-1755. PMID 7142958.
- ^ Soda, K.; Kurihara, T.; Liu, J.-Q.; Nardi-Dei, V.; Park, C.; Miyagi, M.; Tsunasawa, S.; Esaki, N. (1996). "Bacterial 2-haloacid dehalogenases: Structures and catalytic properties". Pure Appl. Chem. 68 (11): 2097–2103. doi:10.1351/pac199668112097.
External links
[edit]- 2-haloacid+dehalogenase+(configuration-retaining) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
