Talk:Two-hit hypothesis

Medicine Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Low	This article has been rated as Low-importance on the project's importance scale.

External links modified

Hello fellow Wikipedians,

I have just modified one external link on Knudson hypothesis. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

Added archive https://web.archive.org/web/20070520061242/http://www.carlonordling.se/Cancer.html to http://www.carlonordling.se/Cancer.html

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).

If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 06:30, 7 May 2017 (UTC)[reply]

Who formulated the hypothesis?

The following can be read in the beginning of the article: "It [the Knudsen hypothesis] was first proposed by Carl O. Nordling in 1953,[1][2] and later formulated by Alfred G. Knudson in 1971.[3]".

I read the paper by Nordling ([1]) and while it discusses the number of mutations required in the genome to develop cancer, it does not as far as I can tell at all relate to the two-hit hypothesis formulated by Knudsen which discusses that a hit (mutation) was required to each allele of the same gene (RB) to cause cancer. I would argue the statement in the Wikipedia article above quoted is false. I can however not access [2].

1. Nordling C (1953). "A new theory on cancer-inducing mechanism". Br J Cancer. 7 (1): 68–72. doi:10.1038/bjc.1953.8. PMC 2007872. PMID 13051507. Archived from the original on 20 May 2007. 2. Marte B (2006-04-01). "Milestone 9: (1953) Two-hit hypothesis - It takes (at least) two to tango". Nature Milestones Cancer. Retrieved 2007-01-22. 3. Knudson A (1971). "Mutation and cancer: statistical study of retinoblastoma". Proc Natl Acad Sci USA. 68 (4): 820–823. doi:10.1073/pnas.68.4.820. PMC 389051. PMID 5279523.

130.241.182.39 (talk) 14:15, 15 January 2019 (UTC)[reply]