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Protein-coding gene in the species Homo sapiens
Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene .[ 5] [ 6]
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.[ 6]
SF3A1 has been shown to interact with SF3A3 [ 7] [ 8] CDC5L .[ 9]
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PDB gallery
1we7 : Solution structure of Ubiquitin-like domain in SF3a120
1zkh : Solution structure of a human ubiquitin-like domain in SF3A1
2dt6 : Solution structure of the first SURP domain of human splicing factor SF3a120
2dt7 : Solution structure of the second SURP domain of human splicing factor SF3a120 in complex with a fragment of human splicing factor SF3a60
