Decylhomocitrate synthase

In enzymology, a decylhomocitrate synthase (EC 2.3.3.4) is an enzyme that catalyzes the chemical reaction

dodecanoyl-CoA + H₂O + 2-oxoglutarate $\rightleftharpoons$ (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA

The 3 substrates of this enzyme are dodecanoyl-CoA, H₂O, and 2-oxoglutarate, whereas its two products are (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming). Other names in common use include 2-decylhomocitrate synthase, 3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase, and (CoA-acylating).

References

• Mahlen A (1973). "Purification and some properties of 2-decylhomocitrate synthase from Penicillium spiculisporum". Eur. J. Biochem. 38: 32–9. PMID 4774124.
• L, Narendra AM, Mehra NK, Saxena R, Choudhry VP (2006). "Fludarabine, cyclophosphamide and horse antithymocyte globulin conditioning regimen for allogeneic peripheral blood stem cell transplantation performed in non-HEPA filter rooms for multiply transfused patients with severe aplastic anemia". Bone. Marrow. Transplant. 37: 745–9. PMID 16518427.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

The CAS registry number for this enzyme class is Template:CAS registry.