Mesembrine
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| IUPAC name
(3aS,7aR)-3a- (3,4-dimethoxyphenyl)- 1-methyl-2,3,4,5,7,7a- hexahydroindol-6-one
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| Identifiers | |||
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |||
| 289.37 | |||
| Molar mass | 289.375 g·mol−1 | ||
| log P | 1.1 | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mesembrine is an alkaloid present in Sceletium tortuosum.[1] One patent claims that mesembrine is a serotonin reuptake inhibitor [2], although there is currently no peer reviewed scientific literature to confirm this claim. It has also been shown to be a PDE4 inhibitor.[3] Mesembrine may contribute to the antidepressant effects of kanna.
References
- ^ Smith M, Crouch N, Gericke N, Hirst M (1996). "Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review". J Ethnopharmacol. 50 (3): 119–30. doi:10.1016/0378-8741(95)01342-3. PMID 8691846.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Pharmaceutical compositions containing mesembrine and related compounds. U.S. Patent 6,288,104
- ^ Mesembrine - an inhibitor of PDE4 that follows structure-activity relationship to rolipram. [1]