File:TAAR1 Amphetamine Dopamine.png

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Summary

Description

English: This is an illustration of a dopamine neuron with co-localized TAAR1 and the effects of a TAAR1 agonist (amphetamine or a trace amine) on dopamine reuptake and effluxion.

This model was based upon information from the three following sources:

Offermanns, Stefan; (eds.), Walter Rosenthal (2008). Encyclopedia of Molecular Pharmacology (2nd ed. ed.). Berlin: Springer. pp. 1219–1222. ISBN 3540389164.
Miller GM (January 2011). "The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity". J. Neurochem. 116 (2): 164–176. doi:10.1111/j.1471-4159.2010.07109.x. PMC 3005101. PMID 21073468.
Eiden LE, Weihe E (January 2011). "VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse". Ann. N. Y. Acad. Sci. 1216: 86–98. doi:10.1111/j.1749-6632.2010.05906.x. PMID 21272013.

Date

10 December 2013, 20:26:55

Source

Own work

Author

Seppi333

Other versions

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File history

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	Date/Time	Dimensions	User	Comment
current	04:23, 4 September 2017	807 × 1,024 (188 KB)	Seppi333	Uploading small fix to a line of text in this image (this is the update from the April 2017 revision of File:TAAR1_Dopamine.svg)
	07:05, 29 January 2016	807 × 1,024 (202 KB)	Seppi333	fix from svg version
	08:35, 17 April 2015	807 × 1,024 (202 KB)	Seppi333	new version w/ different cytosol color
	00:35, 22 May 2014	725 × 920 (179 KB)	Seppi333	rv to SVG variant
	19:50, 23 March 2014	4,028 × 5,111 (1.39 MB)	Seppi333	increase size, update content for review by others before updating svg file
	20:11, 15 March 2014	725 × 920 (179 KB)	Seppi333	update to current svg version
	14:09, 25 February 2014	740 × 925 (173 KB)	Seppi333	Uploading png version of the new svg file
	05:28, 11 January 2014	800 × 975 (85 KB)	Seppi333	Added dopamine to synaptic cleft side of the D2 receptor. Refined minor details (e.g., certain arrowheads).
	02:35, 15 December 2013	800 × 975 (85 KB)	Seppi333	Added post-synaptic DA firing-rate reduction - while not indicated in the picture, this is TAAR1-mediated, presumably through an effect on adjacent inhibitory neurons. (See Miller, FIG 1) Also move "pre-synaptic" and "synaptic cleft" more to the right.
	02:43, 13 December 2013	800 × 975 (82 KB)	Seppi333	Extremely minute detail fix of the gray arrow through DAT.