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Integrin alphaXbeta2

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Integrin alphaXbeta2 (p150,95, CR4) is a complement receptor composed of CD11c and CD18.

External links

Integrin+alphaXbeta2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Complement system

Pathways

C
L
A

Activators/enzymes

Early	C: C1 C1q C1r C1s C4 C4a C4b C2 L: MASP1/MASP2 MBL A: Factor B Factor D Factor P/Properdin
Middle	C3 C3a C3b/iC3b C5 C5a C5b C3-convertase C5-convertase
Late	MAC C5b C6 C7 C8 C9

Inhibitors

CL: C4BP

A: Factor H

Complement receptors

Function

Membrane proteins: cell adhesion molecules

Calcium-independent

IgSF CAM	N-CAM (Myelin protein zero) ICAM (1, 5) VCAM-1 PE-CAM L1 family L1-CAM NRCAM NFASC CHL1 Nectin PVRL1 PVRL2 PVRL3 CADM1 CADM3 CD155
Integrins	LFA-1 (CD11a+CD18) Integrin alphaXbeta2 (CD11c+CD18) Macrophage-1 antigen (CD11b+CD18) VLA-4 (CD49d+CD29) Glycoprotein IIb/IIIa (ITGA2B+ITGB3)

Calcium-dependent

Classical	CDH1 CDH2 CDH3
Desmosomal	Desmoglein (DSG1, DSG2, DSG3, DSG4) Desmocollin (DSC1, DSC2, DSC3)
Protocadherin	PCDH1 PCDH15 PCDH19
Unconventional/ungrouped	T-cadherin CDH4 CDH5 CDH6 CDH8 CDH11 CDH12 CDH15 CDH16 CDH17 CDH9 CDH10

Other

Alpha

A1
A2
A3
A4
A5
A6
A7
A8
A9
A10
A11
AD
AE
AL
AM
AV
AX

Beta

B1
B2
B3
B4
B5
B6
B7
B8

Dimers

Cytoadhesin receptor:	Integrin alpha6beta4 Glycoprotein IIb/IIIa ITGA2B+ITGB3
Fibrinogen receptor:	Macrophage-1 antigen CD11b+CD18
Fibronectin receptor:	Integrin alpha2beta1 Integrin alpha4beta1 Integrin alpha5beta1
Leukocyte-adhesion receptor:	LFA-1 CD11a+CD18 Macrophage-1 antigen CD11b+CD18 Integrin alphaXbeta2 CD11c+CD18
Very late antigen receptor:	Integrin alpha1beta1 Integrin alpha2beta1 Integrin alpha3beta1 VLA-4 CD49d+CD29 Alpha-5 beta-1 Integrin alpha6beta1
Vitronectin receptor:	Alpha-v beta-3 Alpha-v beta-5

see also cell surface receptor deficiencies

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