Adolphe-Marie Gubler
Adolphe-Marie Gubler (5 April 1821 – 20 April 1879) was a French physician and pharmacologist who was born in Metz.
Originally a student of botany, he began his medical studies in 1841 at Paris, where he was a pupil of Armand Trousseau (1801-1867). In 1845 he became an interne des hôpitaux, earning his doctorate in 1849. Afterwards he worked as a physician at the Hôpital Beaujon, and in 1853 earned his agrégation with a thesis on cirrhosis of the liver. In 1868 he was appointed professor of therapy to the medical faculty in Paris, maintaining this position until his death in 1879.
Gubler made numerous contributions in the fields of medicine and pharmacology. He is credited with being the first physician to differentiate between hemotogenous and hepatogenous icterus. His named is associated with Millard-Gubler syndrome, a condition characterized by softening of the brain tissue caused by blockage of blood vessels of the pons. This disease is named in conjunction with Auguste Louis Jules Millard (1830-1915), who initially described the disorder in 1855. The eponymous "Gubler's line" is a line of superficial origin of the trigeminal nerve on the pons, a lesion below which results in the aforementioned Millard-Gubler syndrome.
He was the author of many works on botany, clinical medicine, physiology and pharmacology, with several articles on the latter subject being published in Journal de thérapeutique. Among his better known publications was an 1856 work on hemiplegia titled De l'hémiplégie alterne envisagée comme signe de lésion de la protubérance annulaire et comme preuve de la décussation des nerfs faciaux, and an important book involving pharmacopoeia called Commentaires thérapeutiques du codex medicamentarius which was awarded the Chaussier Prize by the Académie des sciences.
Gubler was a founding member of the Société de biologie, and in 1865 became a member of the Académie de médecine. While still an interne, he was asked by Dr. Trousseau to perform as a travelling companion to a young man who was suffering from emotional distress. While in Milan, Gubler was seriously wounded by a gunshot from his companion, forcing him to spend a year recuperating in Milan.