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WD repeat domain 18

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(Redirected from WDR18)
WDR18
Identifiers
AliasesWDR18, Ipi3, R32184_1, WD repeat domain 18
External IDsMGI: 2158400; HomoloGene: 32573; GeneCards: WDR18; OMA:WDR18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024100
NM_001372085
NM_001372086

NM_175450

RefSeq (protein)

NP_077005
NP_001359014
NP_001359015

NP_780659

Location (UCSC)Chr 19: 0.98 – 1 MbChr 10: 79.8 – 79.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. [5]

Function

[edit]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 forms a nucleolar complex with LAS1L, PELP1, TEX10 called the rixosome which is involved in RNA degradation.[6][7] The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the Polycomb Repressive Complex 1 has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA.[8]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065268Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035754Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: WD repeat domain 18". Retrieved 2017-08-12.
  6. ^ Castle CD, Cassimere EK, Denicourt C (February 2012). "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell. 23 (4): 716–728. doi:10.1091/mbc.E11-06-0530. PMC 3279398. PMID 22190735.
  7. ^ Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020). "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife. 9. doi:10.7554/eLife.54341. PMC 7269676. PMID 32491985.
  8. ^ Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, et al. (April 2022). "Rixosomal RNA degradation contributes to silencing of Polycomb target genes". Nature. 604 (7904): 167–174. Bibcode:2022Natur.604..167Z. doi:10.1038/s41586-022-04598-0. PMC 8986528. PMID 35355014.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.