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Apple pie is good.
{{WPMED|class=B|importance=High}}


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{{FailedGA|2006-04-12}}
{{WP1.0|v0.5=pass|class=B|category=Natsci|VA=yes}}

==Comment==

I think this article would be better if S.I. units were used throughout. Several gallons does not mean much to most of the world. Pete <span style="font-size: smaller;" class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/147.188.171.56|147.188.171.56]] ([[User talk:147.188.171.56|talk]]) 17:30, 22 April 2010 (UTC)</span><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

=Symptoms?=

can someone add more information on the condition rather than the history on it, as i'd like to know what it ACTUALLY does? <span style="font-size: smaller;" class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/122.105.39.231|122.105.39.231]] ([[User talk:122.105.39.231|talk]]) 18:05, 9 June 2009 (UTC)</span><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->


On another note,o There's an interesting book on the subject by Charles Rosenberg, "The Cholera Years: The United States in 1832, 1849, and 1866", primarily it focuses on NYC for reasons of simplicity and symbolism (ie. well established city, so records are easier to find and compare), though it does make some reference to other cholera outbreaks in passing.

== [[Wikipedia:Good articles|Good Article]] [[Wikipedia:Good articles/Nominations|nomination]] has failed ==
The [[Wikipedia:Good articles|Good article]] [[Wikipedia:Good articles/Nominations|nomination]] for [[{{PAGENAME}}]] has failed for the following reason:

:Some areas of the article should be expanded, including the lead section, Transmission, Research, and Other Historical Information. Though not required, it could also use more images, such as those of doctors treating patients, not just the bacteria alone. -- [[King of Hearts|King kof <font color="red">&hearts;</font>]] [[User talk:King of Hearts|<font color="red">&diams;</font>]] [[Special:Contributions/King of Hearts|<font color="black">&clubs;</font>]] [[Special:Emailuser/King of Hearts|<font color="black">&spades;</font>]] 05:24, 12 April 2006 (UTC)

:The mode of toxicity of cholera needs to be expanded as at this stage it's extremely misleading and thus just plain wrong.
:<small>Above posted by [[User:149.167.200.3]] on 10:01, 8 May 2006</small>

==Spelling of Diarrhea/Diarrhoea==
To editor 86.128.86.30, if you're going to change one instance of "Diarrhea" to "Diarrhoea", change them all. That way the article is internally consistent. I'll wait a while for other users' comments, and then maybe revert or change all instances. --[[User:Storkk|Storkk]] 21:20, 16 July 2006 (UTC)
: On second thoughts, I'll just revert, as I've just visited the [[Diarrhea]] page, and it looks like the wiki standard is "Diarrhea" with "Diarrhoea" being a side note, referring to [[spelling differences]] --[[User:Storkk|Storkk]] 21:22, 16 July 2006 (UTC)

:Indeed Storkk - the consensus, as I understand it, is to use either British or American spellings as set when the article was first written and remain internally consistant with that selection. So if this article already uses American spellings then any new addition to this article should keep to this. However if a British editor creates a new article on Disease X and uses 'Diarrhoea', then subsequent American-English speaking editors should respect that too. Unfortunately (as a British-English speaker) Americans generally seem to have started most of the medical articles before we got here :-( [[User:Davidruben|David Ruben]] <sup> [[User talk:Davidruben|Talk]] </sup> 00:51, 17 July 2006 (UTC)
==Cholera and Blood Types==
The cited article shows an epidemiologic correlation betwen ABO blood groups and cholera, and does not advance a genetic rationale. Given the absence of any biologic reason why the arrangement of sugars on the outside of your red cells (ABO group) would have something to do with your resistance to cholera (mediated through the unrelated CFTR chloride channel) its more likely an example of coincidental coassortment of genes. The statements about A, B, and AB appear unsupported and are candidates for removal. Cholera is an ongoing public health threat in parts of the world where A, B, and AB are much more common than in caucasian-majority countries, and if they really did confer relative resistance to cholera, it would be big news, so I doubt it.

I do not claim to be an expert and have not looked at any data but it doesn't seem farfetched to me, as a possibility, it cannot be assumed to be true though i agree. Viruses and bacteria often infect cells by interacting with the carbohydrates on the cell surface in order to find appropriate protein channels to insert genetic material or to gain proximity to a cell for other purposes. Not saying the theory is valid, but further research into a relationship would not automatically be a waste either. Also, just because one blood type might be more susceptible, does not mean the others are resistant to the point of protection, just that they may have infection and/or progression at lower rates. [[Special:Contributions/134.243.210.14|134.243.210.14]] ([[User talk:134.243.210.14|talk]]) 14:57, 11 December 2008 (UTC)

== formatting changes ==

it looks like somebody got an html editor attached to the wiki. there were a lot of nbsp entities, including ones which were commented out. i am truly mystified. additionally, these two refs were hanging out up top with a broken comment:

:<ref name="JPhysiol1995-Cuthbert">{{cite journal | author=Cuthbert AW, Halstead J, Ratcliff R, Colledge WH, Evans MJ | title=The genetic advantage hypothesis in cystic fibrosis heterozygotes: a murine study | journal=J Physiol | year=1995 | pages=449-54 | volume=482 ( Pt 2) | id={{PMID|7714835}}}}</ref>
:<ref name="AmJHumGenet2000-Hogenauer">{{cite journal | author=Hogenauer C, Santa Ana CA, Porter JL, Millard M, Gelfand A, Rosenblatt RL, Prestidge CB, Fordtran JS | title=Active intestinal chloride secretion in human carriers of cystic fibrosis mutations: an evaluation of the hypothesis that heterozygotes have subnormal active intestinal chloride secretion | journal=Am J Hum Genet | year=2000 | pages=1422-7 | volume=67 | issue=6 | id={{PMID|11055897}} }}</ref>

please have a look at the [http://en.wiki.x.io/w/index.php?title=Cholera&diff=85190568&oldid=85125043 diff]. i am quite confused at what happened to get the article into the state it was in when i arrived, and i'm not actually sure i've "fixed" anything. it displays fine in my [[User:Avriette/AOD|browser]], but then mine's a little weird. i don't watch this article, i just stopped by for a look at the bioweapons category. <b>...&nbsp;</b><span style="background-color: #11cbc4;width:52px;height:16px;font-size:12px;p{text-align:center}">[[user:avriette|aa]]:[[user_talk:avriette|talk]]</span> 04:19, 2 November 2006 (UTC)

== Inconsistent dates ==

Under the RESEARCH section:

"The scientists with major contributions to fighting cholera were John Snow, who found the link between cholera and drinking water in 1854, and Robert Koch, who identified V. cholerae as the bacillus causing the disease. The bacterium was originally isolated thirty years earlier by Italian anatomist Filippo Pacini ..."

This clearly implies that Pacini isolated the bacterium 30 years earlier that 1854 -- IE 1824.

However, in the Pacini article, http://en.wiki.x.io/wiki/Filippo_Pacini, it states:

"Pacini ... an Italian anatomist ... famous for isolating the cholera bacillus Vibrio cholerae in 1854, well before Robert Koch's more widely accepted discoveries thirty years later."

So which is it -- 1824 or 1854?

Looking up the Koch article, it looks like 1854 is correct for Pacini, and Koch made his discoveries about cholera in 1883.

Someone may want to do some fact-checking.

== Fix the pagee ==

Someone revert the page.


== Additional Information? ==

There must have been some sort of superstition involved with cholera and how people believed it used to spread and how it could be treated. Would it improve the article if this was added? [[User:87.5.150.10|87.5.150.10]] 15:56, 10 December 2006 (UTC)

:Certainly, '''if''' it is a widespread belief, and if the claim is well referenced.--[[User:Stevenfruitsmaak|Steven Fruitsmaak]] <small>([[User_talk:Stevenfruitsmaak|Reply]])</small> 19:33, 10 December 2006 (UTC)

:In many cases, "bad air" was blamed. [[User:Bwood|Bwood]] 12:42, 26 April 2007 (UTC)

Other than rehydrating the patient, which I imagine cannot go on indefinitely, and prior to antibiotics, or if they don't work, how does a patient survive? The answer, which I don't know, is not clear. [[User:69.14.181.230|69.14.181.230]] 19:14, 2 January 2007 (UTC)
:I'd imagine the body kills it like any other bacteria, its just a matter of keeping them alive while it does it. [[User:Plugwash|Plugwash]] 20:52, 2 January 2007 (UTC)

== March 2, 2007 repair to the MainPage ==

I just repaired the text that was deleted without justification in
[http://en.wiki.x.io/w/index.php?title=Cholera&diff=110823868&oldid=110339423 this edit]. --[[User:Rednblu|Rednblu]] 23:30, 1 March 2007 (UTC)

==Vaccine==
What about vaccine? Is there one? If so, what are the risks/side effects with it?
:There is a vaccine (see the [http://www.cdc.gov/ncidod/dbmd/diseaseinfo/cholera_g.htm#Is%20a%20vaccine%20available%20to%20prevent%20cholera CDC comment]), though it is of "questionable benefit" [http://www2.ncid.cdc.gov/travel/yb/utils/ybGet.asp?section=dis&obj=cholera.htm]. Side effects appear to be the standard for any vaccine (see [http://www.mayoclinic.com/health/drug-information/DR202776#5C585B60-E7FF-0DBD-18B2F494C677D638 here] for specifics). -- [[User:MarcoTolo|MarcoTolo]] 06:13, 25 May 2007 (UTC)

==Contradictory/incomplete data==
The article twice says that a victim of cholera can lose "up to 20[[litre|L]]" of fluid. (This is incongruously equated with 20% of body weight; yet most people in the world weigh significantly less than 100 [[kilogram|kg]]). A later explanation says "up to 16 litres of water" could be lost via the intestines. Now, obviously these details are (slightly) contradictory. Is it 16 or 20L? Or is 20% of total body mass a better value?

Furthermore, none of these figures have an associated time scale. Is the 20L lost over the whole course of the illness, in 24 hours, or what??? Finally, there doesn't seem to be cited source for this claim. It may seem that I am nit-picking, but these issues need to be squared away if this is going to become a [[WP:GA|good article]]. Could one of the regular contributors see to this? Many thanks -- [[User:125.238.205.232|125.238.205.232]] 14:07, 20 June 2007 (UTC)

:Good point. PubMed ref added for up to 36 L loss in 6 days (~6L/day); fixed inconsistency. -- [[User:MarcoTolo|MarcoTolo]] 18:51, 20 June 2007 (UTC)

::Outstanding. Within five hours my question was answered. What a great community of contributors wikipedia has! Thank you very much, MarcoTolo. -- [[User:125.238.205.232|125.238.205.232]] 09:45, 21 June 2007 (UTC)

:::but now it says 36L (20% body weight) which is nonsensical, implying a whopping 180KG avg body weight. maybe change the description to 36L water loss in 6 days and up to a 20% decrease in body mass (check source) <small>—The preceding [[Wikipedia:Signatures|unsigned]] comment was added by [[User:{{{1}}}|{{{1}}}]] ([[User talk:{{{1}}}|talk]] • [[Special:Contributions/{{{1}}}|contribs]]){{#if:{{{2|}}}|&#32;{{{2}}}|}}.</small><!-- Template:Unsigned -->

::::Well, actually it said "up to 36 L (or 20% of body weight)" - its not an average. I've pulled the "20%" figure as the ref only quantifies volume, not percent. Additionally, I'm assuming that the trial participants were receiving IV therapy during the six day period (i.e. some of the 36 litres were "supplemental" losses). -- [[User:MarcoTolo|MarcoTolo]] 23:46, 28 June 2007 (UTC)

==Question==
how long can it last if/once a host body has died and it has not been given a suitable new environment to occupy? Can it survive indefinitely "in the wild" without some form of "animal" host? <small><span class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:66.75.119.203|66.75.119.203]] ([[User talk:66.75.119.203|talk]] • [[Special:Contributions/66.75.119.203|contribs]]) </span></small><!-- Template:Unsigned -->

I seem to recall learning that pumpkin seeds are a treatment for Cholera. Anybody able to confirm? <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/220.233.66.37|220.233.66.37]] ([[User talk:220.233.66.37|talk]]) 22:13, 17 September 2007 (UTC)</small><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

Also, if a victim can be significantly hypotensive within three hours--how can there be any weight loss at all, if the low blood pressure is fatal--or do the majority of victims succumb to dehydration? More detail on massive weight loss is needed. Is it from massive dehydration of all body tissues or are there other mechanisms involved? Thanks [[Special:Contributions/75.37.225.244|75.37.225.244]] ([[User talk:75.37.225.244|talk]]) 04:57, 4 December 2008 (UTC)

== Treatment Section ==

Could a treatment section be added? What can people do once they have contracted this disease - it is obviously not 100% fatal. <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/198.169.119.202|198.169.119.202]] ([[User talk:198.169.119.202|talk]]) 02:05, 11 November 2007 (UTC)</small><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

== End Poverty to end epidemics? ==

I always think that the best way to end this & all epidemics is to end world poverty quickly so all nations can have purified water, etc. Should that be added? Sicknesses caused by poverty also affect, & kill, the rich people too. [[User:Socialism20091011|Socialism20091011]] ([[User talk:Socialism20091011|talk]]) 05:37, 22 January 2009 (UTC)

== Engorged Snood ==

Last time I checked, the snood was a piece of skin hanging down from the beak of a TURKEY. Therefore, considering this article is on HUMAN CHOLERA, I've removed the offending remark in the Symptoms section.

If anyone can prove to me that the snood exists in humans, I'd be glad to hear it. [[User:Russthomas15|Russthomas15]] 11:12, 16 November 2007 (UTC)


==Examples==

Hi, i know another case of this illnes wich is the epidemy of Gran Canaria in 1851. There isn't a single source in english and i know two in spanish wich are:

One from the Canarian Stadistic Institute, page 2 (of the canarian government):

http://www.gobiernodecanarias.org/istac/estadisticas/php/saltarA.php?mid=/istac/notasdeprensa/np_20061124_EvolucionHistoricaPoblacion.pdf

Another this article but only say the location not the article itself:

http://dialnet.unirioja.es/servlet/articulo?codigo=587311


Summary: In 1851 the cholera arrived to Gran Canaria in a ship with infected dress from Cuba, the first dead was a worker woman from a laundry of the capital, along the Summer the illnes spread along the capital and with the people who was fleing from the capital to the rest of the island. The total number of deads was 6000-8000 persons, a 10% of the total population; only in Las Palmas de Gran Canaria 3500, 20% of the population with more than a half of the inhabitants infected.

I don't want put it in the article because i don't know how to put citations, sorry.--[[User:Bentaguayre|Bentaguayre]] ([[User talk:Bentaguayre|talk]]) 19:49, 11 February 2008 (UTC)

=Recovery=
<strike>Article needs some information on how quickly cholera can kill.</strike> Misread. Also, if patient is properly cared for, how long does the illness last before the patient recovers? Is there permanent damage from cholera even if the patient survives? What is the survival rate with treatment? Without treatment?--[[User:Mrs Scarborough|Mrs Scarborough]] ([[User talk:Mrs Scarborough|talk]]) 20:45, 11 February 2008 (UTC)

== Adding information on other outbreaks ==

I was grateful for the work that had gone into this page as I was reading about a cholera outbreak in a town in early 20th-century China. I was disappointed in what appears to be the U.S. and European focus of this article. I was wondering if anyone out there was able to add more information about outbreaks that happened in other places around the globe. For instance, the "sixth cholera pandemic," says that it "had little effect on Europe" except for Russia. Where else did it have an affect since Europe wasn't involved? I would be grateful to see more detailed information on that history if possible.[[User:Idlywiki|Idlywiki]] ([[User talk:Idlywiki|talk]]) 05:04, 15 September 2008 (UTC)

== Waterfowl—The Missing Link in Epidemic and Pandemic Cholera Dissemination? ==
This[http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000173] article in PLoS provides some insight into the spread of cholera, as well as some further sources in its reflist. I'm not sure where such information should be included in the cholera article -- perhaps in the epidemiology section? I think this is an important part of understanding the disease and should be included. [[User:TeamZissou|TeamZissou]] ([[User talk:TeamZissou|talk]]) 21:24, 1 November 2008 (UTC)

= Image =

I think that the image Image:Cholera 395.1.jpg deserves a caption, and otherwise should be removed. [[User:Jimjamjak|Jimjamjak]] ([[User talk:Jimjamjak|talk]]) 11:49, 25 November 2008 (UTC)
:Okay, I found the origin of the image and added a caption.[[User:Jimjamjak|Jimjamjak]] ([[User talk:Jimjamjak|talk]]) 08:40, 4 December 2008 (UTC)

== Removed section on metal band and Polish "vulgarism" ==

The entry on the metal band going under the name "Cholera" was limited, unreferenced and unlinked. The Polish "vulgarism" is not particularly noteworthy: several other Slavic languages (and maybe others, I don't know) use this word as an expletive. I don't think that this information adds any value to the article.[[User:Jimjamjak|Jimjamjak]] ([[User talk:Jimjamjak|talk]]) 15:38, 4 December 2008 (UTC)

== Citations ==
I'm new at wikipedia, so I'm coming here before I delete citation number 27. It uses wikipedia as a source. I think that means we're not allowed to use it, but I'm not sure. Here's the source, just in case you want to check more quickly.
http://nursinggazette.blogspot.com/2007/11/cholera.html
[[Special:Contributions/71.49.57.228|71.49.57.228]] ([[User talk:71.49.57.228|talk]]) 03:40, 6 December 2008 (UTC) new volunteer
:I've removed the reference. There's no need [[WP:BOLD|to be so reticent]] about making such changes yourself. Wikipedia is the encyclopedia that anyone can edit, and that includes you! [[User:Phil Bridger|Phil Bridger]] ([[User talk:Phil Bridger|talk]]) 19:34, 14 January 2009 (UTC)

Revision as of 17:47, 30 April 2010

Apple pie is good.