CYTH4

CYTH4
Identifiers
Aliases	CYTH4, CYT4, DJ63G5.1, PSCD4, cytohesin 4, cytohesin-4
External IDs	OMIM: 606514; MGI: 2441702; HomoloGene: 22750; GeneCards: CYTH4; OMA:CYTH4 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,315,341 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,622,019 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; spleen; ; appendix; ; lymph node; ; periodontal fiber; ; bone marrow cells; ; gallbladder; ; right coronary artery;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; stroma of bone marrow; ; spleen; ; subcutaneous adipose tissue; ; blood; ; superior frontal gyrus; ; thymus; ; dentate gyrus of hippocampal formation granule cell; ; body of femur;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; lipid binding;
Cellular component	plasma membrane; membrane; Golgi membrane; cytosol;
Biological process	regulation of ARF protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	27128
	72318
	ENSG00000100055
	ENSMUSG00000018008
	Q9UIA0
	Q80YW0
	NM_013385; NM_001318024
	NM_028195
	NP_001304953; NP_037517
	NP_082471
	Wikidata
View/Edit Human	View/Edit Mouse

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.^[5]^[6]

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. CYTH4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are very similar.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100055 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018008 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ ^a ^b "Entrez Gene: PSCD4 pleckstrin homology, Sec7 and coiled-coil domains 4".

Morishige M, Hashimoto S, Ogawa E, et al. (2008). "GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion". Nat. Cell Biol. 10 (1): 85–92. doi:10.1038/ncb1672. PMID 18084281. S2CID 6148446.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Venkateswarlu K (2003). "Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity". J. Biol. Chem. 278 (44): 43460–9. doi:10.1074/jbc.M304078200. PMID 12920129.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ogasawara M, Kim SC, Adamik R, et al. (2000). "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors". J. Biol. Chem. 275 (5): 3221–30. doi:10.1074/jbc.275.5.3221. PMID 10652308.
Trofatter JA, Long KR, Murrell JR, et al. (1996). "An expression-independent catalog of genes from human chromosome 22". Genome Res. 5 (3): 214–24. doi:10.1101/gr.5.3.214. PMID 8593609.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100055 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018008 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-6] "Entrez Gene: PSCD4 pleckstrin homology, Sec7 and coiled-coil domains 4".

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References

Further reading