Neuropeptide Y receptor Y2

NPY2R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IK3
Identifiers
Aliases	NPY2R, NPY2-R, Neuropeptide Y receptor Y2
External IDs	OMIM: 162642; MGI: 108418; HomoloGene: 701; GeneCards: NPY2R; OMA:NPY2R - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	155,217,078 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	82,455,391 bp
RNA expression pattern
	Top expressed in
	testicle; ; optic nerve; ; pancreatic ductal cell; ; lactiferous duct; ; prefrontal cortex; ; hypothalamus; ; tibialis anterior muscle; ; nucleus accumbens; ; right coronary artery; ; Brodmann area 9;
	Top expressed in
	median eminence; ; lumbar spinal ganglion; ; arcuate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; anterior amygdaloid area; ; subiculum; ; CA3 field; ; globus pallidus; ; area postrema;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	neuropeptide Y receptor activity; G protein-coupled receptor activity; calcium channel regulator activity; signal transducer activity; protein binding; peptide YY receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; non-motile cilium; cilium;
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; regulation of sensory perception of pain; locomotory behavior; positive regulation of cytosolic calcium ion concentration; positive regulation of peptide secretion; outflow tract morphogenesis; cardiac left ventricle morphogenesis; negative regulation of nervous system process; negative regulation of synaptic transmission; behavioral fear response; negative regulation of excitatory postsynaptic potential; secretion; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of dopamine secretion; negative regulation of secretion; feeding behavior; negative regulation of feeding behavior; nitric oxide mediated signal transduction; neuropeptide signaling pathway; positive regulation of smooth muscle contraction; negative regulation of synaptic transmission, glutamatergic; signal transduction; positive regulation of cell-substrate adhesion; human ageing; chemical synaptic transmission; G protein-coupled receptor signaling pathway; negative regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	4887
	18167
	ENSG00000185149
	ENSMUSG00000028004
	P49146
	P97295
	NM_000910; NM_001370180; NM_001375470
	NM_001205099; NM_008731
	NP_000901; NP_001357109; NP_001362399
	NP_001192028; NP_032757
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.^[5]^[6]

Selective ligands

Agonists

Neuropeptide Y (endogenous agonist, non subtype selective)
Neuropeptide Y fragment 13-36 (NPY₂ selective agonist)
Peptide YY
Peptide YY 3-36 fragment^[7]

Antagonists

BIIE-0246 (CAS# 246146-55-4)
JNJ 5207787 (CAS# 683746-68-1)
SF 11 (CAS# 443292-81-7)

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185149 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028004 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Sep 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
^ "Entrez Gene: NPY2R neuropeptide Y receptor Y2".
^ Murphy KG, Dhillo WS, Bloom SR (Dec 2006). "Gut peptides in the regulation of food intake and energy homeostasis". Endocrine Reviews. 27 (7): 719–27. doi:10.1210/er.2006-0028. PMID 17077190. S2CID 24899878.

External links

"Neuropeptide Y Receptors: Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

Wan CP, Lau BH (Feb 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.
Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (Jul 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. Bibcode:1992PNAS...89.5794H. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422.
Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL (Nov 1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype". The Journal of Biological Chemistry. 270 (45): 26758–61. doi:10.1074/jbc.270.45.26758. PMID 7592910.
Lynch JW, Lemos VS, Bucher B, Stoclet JC, Takeda K (Mar 1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line". The Journal of Biological Chemistry. 269 (11): 8226–33. doi:10.1016/S0021-9258(17)37183-1. PMID 8132547.
Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA (Feb 1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor". Molecular Pharmacology. 49 (2): 224–8. PMID 8632753.
Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4661–5. Bibcode:1996PNAS...93.4661Y. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460.
Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF, Yang-Feng TL, Thompson DA (Dec 1996). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene". Genomics. 38 (3): 392–8. doi:10.1006/geno.1996.0642. PMID 8975716.
Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (Jul 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". The Journal of Biological Chemistry. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
Caberlotto L, Fuxe K, Rimland JM, Sedvall G, Hurd YL (Sep 1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain". Neuroscience. 86 (1): 167–78. doi:10.1016/S0306-4522(98)00039-6. PMID 9692752. S2CID 45849983.
Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M (Jul 2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning". Molecular Pharmacology. 60 (1): 124–34. doi:10.1124/mol.60.1.124. PMID 11408607. S2CID 11573265.
Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. S2CID 31244551.
Hyland NP, Sjöberg F, Tough IR, Herzog H, Cox HM (Jun 2003). "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues". British Journal of Pharmacology. 139 (4): 863–71. doi:10.1038/sj.bjp.0705298. PMC 1573894. PMID 12813010.
Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS (Sep 2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits". Diabetes. 53 (9): 2461–6. doi:10.2337/diabetes.53.9.2461. PMID 15331560.
Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B (Feb 2021). "Structural basis for ligand recognition of the neuropeptide Y Y2 receptor". Nature Communications. 12 (1): 737. doi:10.1038/s41467-021-21030-9. PMC 7854658. PMID 33531491.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185149 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028004 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7559383-5] Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Sep 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.

[entrez-6] "Entrez Gene: NPY2R neuropeptide Y receptor Y2".

[pmid17077190-7] Murphy KG, Dhillo WS, Bloom SR (Dec 2006). "Gut peptides in the regulation of food intake and energy homeostasis". Endocrine Reviews. 27 (7): 719–27. doi:10.1210/er.2006-0028. PMID 17077190. S2CID 24899878.

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