Jump to content

File:Vancomycin resistance.svg

Page contents not supported in other languages.
This is a file from the Wikimedia Commons
From Wikipedia, the free encyclopedia

Original file (SVG file, nominally 2,103 × 720 pixels, file size: 1.4 MB)

Summary

Description
English: Diagram depicting the action of the antibiotic vancomycin and one way bacteria have evolved resistance to it.

Background: The bacterial cell wall consists of strands of repeating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) subunits. The NAM subunits have short peptide chains attached to them. (The exact composition of these can vary. The proximal alanine is usually L-ala and the distal two are usually D-ala.) These peptide chains are involved in forming cross-links between the strands of the cell wall. These cross-links are essential to a functioning cell wall.

1. Vancomycin is added to the bacterial environment while it is trying to synthesize new cell wall. Here, the cell wall strands have been synthesized, but not yet cross-linked.

2. Vancomycin recognizes and binds to the two D-ala residues on the end of the peptide chains. However, in resistant bacteria, the last D-ala residue has been replaced by a D-lactate, so vancomycin cannot bind.

3. In resistant bacteria, cross-links are successfully formed. However, in the non-resistant bacteria, the vancomycin bound to the peptide chains prevents them from interacting properly with the cell wall cross-linking enzyme.

4. In the resistant bacteria, stable cross links are formed. In the sensitive bacteria, cross-links cannot be formed and the cell wall falls apart.
Date
Source Own work
Author Mcstrother
Other versions

[edit]

Licensing

I, the copyright holder of this work, hereby publish it under the following license:
w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 3.0 Unported license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

Captions

Add a one-line explanation of what this file represents

Items portrayed in this file

depicts

9 April 2011

1,471,308 byte

720 pixel

2,103 pixel

image/svg+xml

3c0d1acacace3982f049c89728c41228392cf75b

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current18:27, 3 October 2023Thumbnail for version as of 18:27, 3 October 20232,103 × 720 (1.4 MB)SantanyinerFile uploaded using svgtranslate tool (https://svgtranslate.toolforge.org/). Added translation for ca.
02:08, 10 September 2011Thumbnail for version as of 02:08, 10 September 20112,103 × 720 (1.65 MB)McstrotherUpdated to reflect correct mechanism of cross-linking.
14:57, 3 May 2011Thumbnail for version as of 14:57, 3 May 20112,103 × 720 (1.65 MB)McstrotherChanged fonts to Liberation Sans
03:32, 10 April 2011Thumbnail for version as of 03:32, 10 April 20112,103 × 720 (1.65 MB)Mcstrother{{Information |Description ={{en|1=Diagram depicting the action of the antibiotic vancomycin and one way bacteria have evolved resistance to it. Background: The bacterial cell wall consists of strands of repeating N-acetylglucosamine (NAG) and N-acety

The following 2 pages use this file:

Global file usage

The following other wikis use this file:

Metadata