File:LDLR pathway.png
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Summary
| Description | LDL Receptor Pathway. LDL particles (blue triangles) bind the LDL receptor (red) on the cell membrane. The receptors associate with clathrin (green) with the adaptor protein adaptin (purple), and cluster in clathrin-coated pits, or caveolae (1). These pinch off as clathrin-coated vesicles (2). As the clathrin dissociates from the vesicle and returns to the cell surface (3), the vesicle fuses with a late endosome (4). The low pH in the late endosome causes the dissociation of the LDL from its receptor, which returns to the cell surface via a recycling vesicle (5). The LDL is degraded in the lysosome (6) and its cholesterol is incorporated in the lysosomal membrane, while its protein component is hydrolyzed to amino acids that diffuse to the cytoplasm. |
| Date | |
| Source | Own work |
| Author | InfoCan |
| Permission (Reusing this file) |
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I, the copyright holder of this work, release this work into the public domain. This applies worldwide. In some countries this may not be legally possible; if so: I grant anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 18:34, 10 January 2008 | | 960 × 720 (28 KB) | InfoCan | {{Information |Description=LDL Receptor Pathway. LDL particles (blue triangles) bind the LDL receptor (red) on the cell membrane. The receptors associate with clathrin (green) with the adaptor protein adaptin (purple), and cluster in clathrin-coated pit |
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