Jump to content

File:Factor XIII activation via thrombin.svg

Page contents not supported in other languages.
This is a file from the Wikimedia Commons
From Wikipedia, the free encyclopedia

Original file (SVG file, nominally 1,000 × 900 pixels, file size: 5 KB)

Summary

Description
English: Heterotetrameric factor XIII is activated to XIIIa, which crosslinks fibrin in blood coagulation.

1. Thrombin (IIa) cleaves off the activation peptides in the presence of fibrins.

2. XIIIB-subunits (gray) dissociate from the XIIIA-dimer in the presence of calcium ions (Ca2+) and fibrins.

3. XIIIA-dimer conformation changes and its central catalytic domain is now available for substrates.

XIIIA-subunit domains:

  • Pink: activation peptide (N-terminal)
  • Cyan: β-sandwich
  • Green: catalytic domain
  • Blue: β-barrel 1
  • Red: β-barrel 2 (C-terminal)

Each XIIIB-subunit has 10 sushi domains (20 in total per XIII heterotetramer)

Source for info (picture adapted from figure 7):

Date
Source Own work
Author 5-HT2AR

Licensing

I, the copyright holder of this work, hereby publish it under the following license:
Creative Commons CC-Zero This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication.
The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.

Captions

Add a one-line explanation of what this file represents

Items portrayed in this file

depicts

inception

16 November 2019

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current21:15, 16 November 2019Thumbnail for version as of 21:15, 16 November 20191,000 × 900 (5 KB)5-HT2ARUser created page with UploadWizard

The following page uses this file:

Global file usage

The following other wikis use this file:

Metadata

This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.

If the file has been modified from its original state, some details may not fully reflect the modified file.

Retrieved from "http://en.wiki.x.io/wiki/File:Factor_XIII_activation_via_thrombin.svg"