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CMA1

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CMA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCMA1, CYH, MCT1, chymase, chymase 1
External IDsOMIM: 118938; MGI: 96941; HomoloGene: 55606; GeneCards: CMA1; OMA:CMA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308083
NM_001836

NM_010780

RefSeq (protein)

NP_001295012
NP_001827

NP_034910

Location (UCSC)Chr 14: 24.51 – 24.51 MbChr 14: 56.18 – 56.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chymase is an enzyme that in humans is encoded by the CMA1 gene.[5]

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000092009Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022225Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Caughey GH, Schaumberg TH, Zerweck EH, Butterfield JH, Hanson RD, Silverman GA, Ley TJ (May 1993). "The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression". Genomics. 15 (3): 614–20. doi:10.1006/geno.1993.1115. PMID 8468056.
  6. ^ "Entrez Gene: CMA1 chymase 1, mast cell".

Further reading

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