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ABI gene family member 3

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(Redirected from ABI3)
ABI3
Identifiers
AliasesABI3, NESH, SSH3BP3, ABI family member 3
External IDsOMIM: 606363; MGI: 1913860; HomoloGene: 9505; GeneCards: ABI3; OMA:ABI3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135186
NM_016428

NM_001163464
NM_025659

RefSeq (protein)

NP_001128658
NP_057512

NP_001156936
NP_079935

Location (UCSC)Chr 17: 49.21 – 49.22 MbChr 11: 95.72 – 95.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.[5][6][7]

Function

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This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108798Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018381Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M (Nov 2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim Biophys Acta. 1493 (1–2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.
  6. ^ Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S (Apr 2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.
  7. ^ a b "Entrez Gene: ABI3 ABI gene family, member 3".
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Further reading

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